A generally inflamed state is also characteristic of cachexia. The inflammatory markers implicated in this dreadful condition are interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-a), interleukin-1beta (IL-1beta) and interferon-gamma (INF-gamma). Many studies have found that the first, interleukin-6 (IL-6), may be the most important factor affecting the maintenance of body mass (see above link). IL-6 has been found in higher levels in cancer patients with weight loss than in patients with the same disease, but without any weight loss, for example. In another, IL-6 was the only inflammatory marker that was elevated in all 28 patients, and it increased as they approached death. Research on mice has shown that IL-6 neutralising antibodies prevented cachexia, while a study on humans found that administering IL-6 decreased muscle protein synthesis. Additionally, IL-6 may promote tumour growth.
|A turmeric flower.|