Friday, 21 July 2017

The Benefits of Eating Hemp Seeds

Hemp is one of the most misunderstood plants used by humans. Although it does not contain enough THC to cause a psychoactive effect, unlike the cannabis strains, guilt-by-association has meant that hemp seeds were actually banned as a food substance in Australia until April 2017! Even its many industrial uses, such as safe, natural bioplastic, have been thrown under the bus, despite its versatility, water efficiency and benefits in farmland management. Thankfully now, we Australians can enjoy the health benefits of hemp seeds legally and without unnecessary, condescending labels.

Hemp seeds are one of the only complete sources of plant protein. They contain 20 different amino acids, and nine of them are the ones that our bodies cannot produce. Three tablespoons of hemp seeds contains ten grams of protein, so it is a perfect food for vegetarians and vegans. Hemp is particularly high in the amino acid arginine, which is beneficial for heart health. A higher dietary intake of arginine is associated with lower levels of C-reactive protein, an inflammatory marker that helps to indicate cardiovascular disease risk. Three tablespoons of hemp seeds also contains one gram of fibre, which many people do not eat enough of. Eating enough fibre can prevent constipation without the use of laxatives, and aids detoxification.

Many people also do not consume enough of the essential fatty acids; the omega-6 linoleic acid and the omega-3 alpha-linolenic acid. These are present in hemp at a ratio of 2-3:1, which is considered the ideal proportion for a healthy diet. The dietary ratio of omega-6 to omega-3 fats is typically far out of balance, with proportions of 20-30:1 common. Why is this harmful? While necessary in small amounts, omega-6 fatty acids feed into a pathway that produces pro-inflammatory chemicals, and inflammation is known to fuel many chronic illnesses. Omega-3 fats feed the anti-inflammatory pathway but compete for the same enzyme as omega-6s, so these can help to prevent illness. In fact, studies on hemp seed oil or the essential fatty acids it contains have found that they can improve some markers that indicate cardiovascular disease risk.

Hemp seeds are also high in some minerals and vitamins, especially calcium, magnesium, iron and vitamin E. Magnesium deficiency is particularly common, and it is estimated that if everyone had an optimal intake of the mineral, millions of deaths worldwide would be prevented every year. Why? Well, it is involved in over 300 biochemical reactions, from heart rhythm to energy production. Overall, the nutritional value of hemp means that it could save and improve millions of lives if it were treated like just another food. Why did the Australian government, among others, jump to such illogical conclusions about the fear of "getting high" in the first place?

Wednesday, 19 July 2017

Brain Damage Reversed By Oxygen Therapy

Brain injuries are currently notoriously difficult to treat, and so usually result in death or permanent disability. Fortunately now, researchers and clinicians are looking into regenerative therapies, such as the BioQuark team who are soon to publish their initial results on reversing brain death with a stem cell-based treatment. Another essentially natural therapy that shows potential in reversing brain damage is oxygen therapy, which managed to save an American toddler from a life of severe disability.

Oxygen therapy could mean freedom for many with brain injury.
Source: Shahriar Sovon.
Eden Carlson, a two-year-old girl whose heart did not beat for two hours after drowning, showed deep injury to the grey matter of her brain, and cerebral atrophy involving both the grey and white matter. She could no longer speak, walk or respond to others talking, but would uncontrollably shake her head and squirm around. In what could be described as a miracle, a course of oxygen treatments was able to reverse the vast majority of this damage. While her very young age and early intervention played a role in her recovery, this may pave the way to a better life for so many others. The extent of her injuries inspired one of her doctors to give her hyperbaric oxygen therapy (HBOT). HBOT delivers oxygen to a patient at a higher than atmospheric pressure, through a sealed and pressurised chamber. This is aimed at increasing tissue repair beyond what would occur normally. As HBOT was unavailable at the time, doctors gave her oxygen therapy at air pressure for 45 minutes, twice a day, starting at 55 days after her accident. After three weeks, Eden became more alert, squirmed less and had more movement in her arms and hands. She was able to laugh, speak short sequences and regained some ability to eat normally. Then, she relocated to New Orleans, where she could receive hyperbaric oxygen. After only ten treatments, her mother saw that she was back to "near normal, except gross motor function", so she began physical therapy alongside HBOT. After 39 treatments, her walking improved, her speech was even better than before the accident, and overall she showed near normal motor function, cognition and scan results. The team studying Eden say that they have never seen any therapy reverse brain damage in this manner before. They don't fully understand it either, but it is clear that oxygen therapy can fight inflammation and boost cellular survival and repair.

This, however, is not the first time that hyperbaric oxygen therapy has been shown to promote healing in brain injury. Multiple studies have found improved survival and clinical outcomes, with the earliest dating back to the 1960s. Unfortunately delayed treatment, subjective assessment and inappropriate paradigms are preventing oxygen from becoming a mainstream therapy, but hopefully the case of Eden will trigger more demand for it.

Friday, 14 July 2017

Vitamin K2 May Help Those With Rheumatoid Arthritis

Rheumatoid arthritis (RA) is one of the most debilitating chronic illnesses known to humanity. It is an inflammatory disease that affects the whole body, but mostly the joints. We know it is most likely an autoimmune disease, but so far research into causative factors has been centred around genetic predisposition; microbes; allergies; abnormal gut permeability; and diet and lifestyle factors. Now, new research is showing that vitamin K2 may play a key role in fighting the disease.

Natto on rice. Source: Shades0404 (CC: 2.5)
There are several forms of vitamin K. Vitamin K1 is also known as phylloquinone and comes from plant foods, while there are several types of vitamin K2, all known as menaquinone. They come from animal foods and are produced by bacteria. The most important form of K2 for commercial use is MK-7, and is known for its benefits in cardiovascular health and bone strength. It is more bioavailable than MK-4, which has been found in a clinical trial to improve the symptoms and biochemical markers of RA. To see if MK-7 would be even better, researchers divided 84 patients with RA into two groups: one receiving 100 micrograms of K2's MK-7 form, and the other getting a placebo. After three months, markers of inflammation were significantly lower in the treated group, as well as RA disease activity scores. Active levels of osteocalcin, an important marker of bone health, also improved, and all of these benefits were seen in relation to increased levels of MK-7 in the blood. These results are very important partly because of the side effects caused by drugs prescribed for RA. While the disease itself is debilitating, the drugs can be worse enough that many people have to stop taking them.

So where exactly can we get vitamin K2, especially the MK-7 form? Besides supplements, natto and some types of cheese are sources of MK-7. Natto is a fermented soy food from Japan, and although it's very much an acquired taste, it is the best source of the best vitamin K. Some types of meat, cheese and eggs contain the MK-4 form, which is still effective, although less active. Green leafy vegetables contain vitamin K1, and are our main source of dietary vitamin K in the West. This is much less active than vitamin K2 and mainly supports homeostasis. Finally, the MK-10 and MK-13 forms of vitamin K2, which are produced by colonic bacteria, are poorly absorbed and do not provide much activity. While more research on vitamin K2 and RA are probably needed, its use against the disease looks promising, and maybe it's time to suck it up and learn to like natto.

Wednesday, 12 July 2017

Can a Diet Reverse Wrinkles?

Millions of dollars every year are spent on creams and cosmetic procedures in the hope that they will banish wrinkles, puffy eyes and overall poor skin quality. But what is the point when you are still aging on the inside? Aging is a systemic problem, and one of the best tools in the fight against it is changing your diet. As two women found out for themselves, what improves your health on the inside can also benefit you on the outside.

A blood orange would have more power against AGEs than a
typical orange. Source: Dvortygirl
We already know that smoking and excessive sun exposure speed up skin aging (and physical decline overall in the case of smoking). Many of us know that oxidative stress speeds up aging and contributes to disease. However, it has only recently become known that advanced glycation end-products (AGEs) are a key driver of aging throughout the body. These are produced by high blood sugar, which tangles in tissue proteins, and by certain cooking methods. The average daily diet in countries like the UK and Australia contains 15,000 kilounits of AGEs, but we should aim for no more than 5,000-8,000 kilounits. They are hard to clear once formed, and cause a vicious cycle of oxidative stress, inflammation and damage. As nutritionist and skin specialist Karen Fischer found, wrinkles and sagging skin are caused in part by these nasty little compounds. To reduce their formation, it is best to limit your intake of red meat, dairy, processed foods and added sugar, and to increase your intake of red, purple and black plant foods.

To test out Fischer's diet, some at The Daily Mail enlisted the help of two women willing to try it for 28 days. Both before and after they started, skin wrinkling, sagging, redness and pore size were measured with a Visia scanner, and AGE damage was measured by a TruAge scanner. Their diet began with a three day detox, where meat and caffeine were forbidden but unlimited fruit and vegetables were allowed. Then, they got into a pattern of eating where some fish, poultry and caffeine were permitted again (but not sugar, dairy or alcohol). Fischer recommends that half of lunch and dinner plates be filled by vegetables, one quarter by low-AGE protein (fish, poultry, beans or lentils) and the remaining quarter by low-AGE wholegrains (such as quinoa, basmati rice or sweet potato). She recommends that most drinks be limited to water, herbal tea or vegetable juice, and advises supplementation with purple juice shots and anything else, such as magnesium, that is needed by the individual. The way we cook matters too: baking, grilling, frying and barbecuing increase AGE formation - the browner it is, the more AGEs there are - while steaming and making stews, curries, casseroles and soup inhibit them. Spices such as turmeric, ginger, cinnamon and cloves reduce AGE production, as do acids like lemon and lime juice.

So how did it work? One of the women, 42 year old Kate Habberley, went from a TruAge score of 39 to 33. Her Visia scan showed a 9% reduction in redness, smaller pores and an overall improved skin texture. She also lost 12 pounds (about 6kg), and has no plans to return to her previous diet. Debra Cull, 54, went from her TruAge score of 49 down to 46 in 28 days. Her Visia scan showed a 6% improvement in skin texture and an 11% reduction in open pores, as well as less redness. She did notice that her skin was fresher, clearer and less "crepey" around the eyes; lost 5 pounds; and to her surprise, her hot flashes disappeared! The only thing she really misses from her old diet is wine. If these are the results you get from AGE-counting rather than kilojoule-counting, why not change our way of thinking about food for health?

Friday, 7 July 2017

Magnesium Supplementation May Help Relieve Depression

Depression is a sadly common mental health condition that affects millions of people in Australia and around the world. To make things worse, assumptions about a person's competency if they are mentally ill in any way often stops people from being diagnosed and treated. And then there is the side effects from socially-sanctioned antidepressant drugs, prescribed after being given the even more disempowering explanation of 'you have a chemical imbalance so you need medication'. However, there are many natural therapies for depression that give you back your power, as they are more preventive in nature and help your body to heal itself. One of these, as a recent study shows, is magnesium.

Food sources of magnesium.
This study involved 126 men and women who suffered from mild to moderate depression. Sixty-two were given a supplement containing 248mg of magnesium (as magnesium chloride, not the best supplemental form) for six weeks, and then spent six weeks with no supplementation. The others first spent six weeks taking no magnesium, and then swapped with the first group for the second half. All volunteers were given questionnaires to evaluate their depression and anxiety at the start of the study and every two weeks during treatment. During supplementation, depression and anxiety scores improved significantly, and participants were less likely to suffer from headaches. During the control period, however, depression scores did not change and anxiety worsened. As their symptoms showed improvement in two weeks, magnesium could be a rapid-acting remedy for mild and moderate depression, with a wide range of side benefits. And if you are worried about negative social attitudes towards depression, magnesium is indicated for so many health complaints that a supplement implies nothing.

So, why? What does magnesium do? Magnesium is involved in over 300 biochemical reactions in the body, from energy production to the synthesis of neurotransmitters that control mood. If you are deficient, and many people are, then these chemical reactions are limited. Of course, magnesium is not the only nutrient that we need to make neurotransmitters. B vitamins, particularly B12, folate (B9), B6 and niacin (B3), are essential co-factors in neurotransmitter production. Deficiencies do not just affect mood, but overall brain function and memory. A balance of omega-3 and -6 essential fatty acids is also important, as they are a part of nerve cell membranes and play a role in communication between cells. Impaired communication affects things like mood, memory and function in general. Vitamin D deficiency is another common problem, which can contribute to depression by altering gene expression and the ability to control inflammation. Overall, the 'chemical imbalance' is more complex than conventional medicine tells you, and we have far more control over it too.

Thursday, 6 July 2017

Progress in Reviving the Brain Dead

So many of us have lost relatives or friends to accidents and conditions resulting in brain death, and even if we haven't, many would like to see the end of such tragedies. Fortunately, some good news is developing. Revita Life Sciences, a company focused on advancing regenerative medicine, has announced that its clinical trials on interventions for brain death will continue. This comes after their study was inappropriately removed from the Indian Council of Medical Research (ICMR) database, despite the fact that this council has no regulatory oversight on such research in India.


Bringing back those who have
drowned was once a new idea!
Source: Wellcome Images
So-called "moral crusaders" accuse Revita Life of "playing God", and assumed that the removal meant that the Indian government was on their side. However, the Central Drugs Standard Control Organisation (CDSCO), Drug Controller General of India, had no objection to the trial. Regulatory approval is not required for research on those who are legally dead, although consent from the IRB and family members is still necessary. Death is defined as the cessation of the biological functions that keep us alive. Brain death is the loss of brain function, including involuntary processes such as breathing, and is the legal definition of death. It is also the final pathological process that over 60 million people suffer each year, and it is hoped that at least some of these people will be saved in the future by this research.

What this study primarily involves is the intrathecal administration (injection into the spinal canal) of the patient's own stem cells, derived from their fat and bone marrow tissue, twice a week. Of course, a list of other interventions is being used too, hence the study title of “Non-randomized, Open-labelled, Interventional, Single Group, and Proof of Concept Study with Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury”. It sounds like a mouthful, but a more pleasant one than hospital staff telling you to say goodbye to someone you love. So far, initial outcomes range from minor blood pressure changes with painful stimuli, to eye opening and finger movements with temporary or permanent EEG pattern changes. This is impressive for the first human trial on reversing "irreversible" damage to the most difficult to heal organ. But perhaps a simple natural intervention could complement it? There have been at least a couple of cases where high doses of fish oil were able to promote healing from brain injury, by both stopping the inflammation which continues to kill neurons, and stimulating cell growth. Both of these patients were in a coma.

While essentially resurrecting the brain dead is controversial now, consider this: resuscitation of people who had drowned was once a very new and probably controversial concept. In the 1760s (when learning to swim would have been out of reach for most), a few wealthy Dutch men decided to form a society focusing on recovering drowned people. With the techniques and ethical changes they began to develop, they saved many lives, perhaps including someone you know. Like me, you may have also had to learn them yourself. Life extension has a much more human face than the popular fear that we will all be forced to become cyborgs or androids. In fact, humanity is strengthening as a result.

Wednesday, 5 July 2017

The Ageless Generation Appears

Usually when we hear about life expectancy rising and death rates falling, the good news is accompanied by handwringing about living in a "greying world" and a supposedly increasing proportion of people who must depend on others for health reasons. But times are changing, as life at certain age groups is not what it was even one generation ago.

The sun rises on a new era.
Source: vonderauvisuals (CC: 2.0)
Who would have thought that this could be a 51 year old woman's life: teaching yoga at a hip hotel and club; sharing clothes and yoga challenges with her 19 year old daughter; and in love with travelling? Such is the life of Polly Kemp, and it's becoming increasingly common. While she is "under no illusion" that she is or looks 19, she knows that she is far more youthful than her mother at the same age. She says, "When I hear the term “middle-aged”, I have to stop and think, 'Is this meant to be me?' I don’t polish silver or plan menus, and I’m not interested in housework. I am also spontaneous  and I don't think that's a quality traditionally associated with middle age". Even the author of the article adds that 40 years ago, she would have pictured her 53 year old self as having much shorter, greyer hair, and wearing "frocks and face powder" instead of jeans and CC cream. And it isn't just these two women, either. In a survey of over 500 women performed by the UK Telegraph, 96% of women over 40 do not consider themselves to be "middle-aged". Ninety percent said they had a younger attitude than their mothers at the same age; 84% used products and services aimed at younger women; and almost two thirds said they felt as vibrant and young as they ever had. Unfortunately, the media hasn't caught up to these changes, choosing to hold onto the old ways. Women over 40, 50, 60 and sometimes even older are no longer confining their lives to, as the Telegraph describes, "lawnmowers and Rotary Clubs, cheese and wine parties, elastic waists, river cruises and walking tours of Madeira". I myself could not imagine my friends of those ages living in such a restricted way!

The "ageless generation", also referred to as "perennials", is also gaining ground in a literal sense. As far back as 1939, British statisticians Major Greenwood and J.O. Irwin found that aging seems to stop at around 90! Even they were confused, stating that "At first sight this must seem a preposterous speculation". Not only did their findings seem counterintuitive, but 1939 was also a bad year to attempt making scientific history because of other world events. Much more recently, Michael Rose has done more research on the matter, with even data from other species showing that there is a point where aging stops if you live long enough - at about 90 for humans, but at different times for other animals.

Tuesday, 4 July 2017

Don't Want Coffee? Try Cocoa Instead

In many countries, most people drink coffee on a regular basis, whether we like to pair the buzz with work or socialising. Some people, however, are addicted to caffeine or just can't tolerate it, and so are looking for an alternative that boosts brain function and energy without being so stimulating. One such alternative could be cocoa, especially when paired with spearmint.

Cocoa pods and seeds. Source: Lolay (CC: 2.0)
While coffee does contain polyphenols with a wide range of health benefits, even decaffeinated beverages can cause heartburn and overstimulation in some people. Too much coffee can deplete levels of noradrenaline, which helps us with energy and cognition. Other natural compounds, such as those in cocoa and spearmint, boost cognition by preserving neurotransmitters like noradrenaline, so they may be a better alternative. Cocoa also protects and improves the health of our blood vessels, right down to the capillaries, which ensures delivery of oxygen and nutrients both now and in the future. Many dementia cases are in fact caused by poor microvascular health.

Of course, it is the quality of the cocoa that makes all the difference. In a study of sixty older adults, with an average age of 73 and all with either hypertension or type II diabetes, volunteers had two cups every day of a cocoa beverage that was either rich or depleted in flavonols. Everyone had their cognitive function and neurovascular coupling measured before the study, on day 1 and on day 30, the last day. Neurovascular coupling is the ability of blood vessels to increase the delivery of oxygen and nutrients to areas of the brain that suddenly become more active while you're doing something. After 24 hours, volunteers with previously poor neurovascular coupling had this parameter improve by 10.6%, and at 30 days their scores on a test measuring attention significantly improved. Before the study, they took an average of 167 seconds (2 minutes and 47 seconds) to complete the test, but after 30 days this was shortened to 116 seconds (just under 2 minutes). Surprisingly, both flavonol-rich and poor drinks had the same effects. Another study on younger adults, with an average age of 33, found that it may be the small amount of caffeine in cocoa together with another phytochemical, theobromine, that is responsible for its cognition-boosting effects. It is most likely to be the result of all phytochemicals in cocoa working together.

As for spearmint, some of its phenolic compounds inhibit the acetylcholinesterase enzyme, thus increasing levels of the neurotransmitter acetylcholine. This is critical for cognitive function and memory. One phenolic, rosmarinic acid, has been shown to protect neurons in the brain's memory centres against oxidative stress, which can kill cells if severe enough. To make things even better, rosmarinic acid and some other phenols in spearmint can even increase the growth factors required to make new brain cells! The old paradigm of "no new neurons" is gone. Overall, perhaps hot chocolate isn't so bad after all, but watch for quality and sugar content.

Thursday, 29 June 2017

Could Pomegranates Help Menopausal Women?

Menopause comes to every woman, and unfortunately it is almost always accompanied by unpleasant symptoms and degenerative age-related changes. But do we have to just accept this? No, while we can't have children forever, there are many plant medicines which can help us avoid the aging effects of menopause. Now joining the more well-known remedies such as black cohosh and soy, is the pomegranate, a fruit that bears a striking resemblance to our ovaries.

The traditional Doctrine of Signatures uses the appearance of some fruits, vegetables and herbs as a rule of thumb when remembering their health benefits. This may also apply to pomegranates, which look like the ovaries of a woman on the inside, as experiments have found that they contain a phytoestrogen functionally similar to oestrone (one form of oestrogen). In a study on rats, those that had their ovaries removed and were given nothing suffered the same problems as menopausal women: bone loss, depression and atrophy of the reproductive organs. However, administration of a pomegranate extract (of the juice and seeds) reduced depression and prevented atrophy of the bones and reproductive system. Bone volume was greater, and bone tissue was less porous, in rats given pomegranate extract. Markers of bone tissue breakdown were also normalised by the pomegranate extract, but remained higher in the control group. Although there are some differences between rats and humans, this study suggests that pomegranate fruit extract could protect us against some of the worst problems caused by menopause. But unlike hormone replacement therapy, there isn't a risk of the extract over-stimulating oestrogen receptors and causing overgrowth of breast and reproductive tissue. Pomegranates are known as selective oestrogen receptor modulators (SERMs), which are strong enough to benefit us without toxic effects.

On top of this, pomegranates are rich in antioxidants such as vitamin C. We typically associate antioxidants like vitamin C with the protection of our cells and their DNA against free radicals, but hormones are not exempt from oxidative damage. One lab study has found that vitamin C can restore the function of hormones such as oestrogen, progesterone and testosterone after oxidation. This may mean that we do not need to produce as much of these hormones to bring about the same beneficial effects. Of course, antioxidant-rich fruits including pomegranates have significant effects on our cardiovascular health too, which is important for post-menopausal women as the risk of heart and blood vessel problems dramatically increases. Overall, it looks like pomegranates are yet another natural alternative to just "putting up with" the annoying and damaging effects of menopause, but more research on human women needs to be done.

Wednesday, 28 June 2017

Vegetarian Diets May Be More Effective for Weight Loss

On the Internet, being vegetarian can earn you a lot of vicious criticism for daring to be different, but it turns out that, at least in some situations, vegetarians may have the last laugh when it comes to health. A new study shows that people needing to lose weight may be better off going on a vegetarian diet, as it not only helped them lose weight more effectively but also improved their metabolism.

A labeled Tamil vegetarian meal.
Source: KARTY JazZ (CC: 4.0)
For this study, 74 people with type II diabetes were randomly assigned to either a conventional anti-diabetic diet or a vegetarian one, high in vegetables, fruit, nuts, grains, legumes and seeds. The only animal food allowed was one portion of low-fat yoghurt a day. Although both diets had the same caloric restriction, the vegetarian diet was twice as effective in reducing body weight, resulting in an average of 6.2kg of weight lost compared to 3.2kg. It wasn't simply weight loss, either. Using magnetic resonance imaging (MRI), the doctors performing this study then looked at how fat tissue was stored in the patients' thighs. Fat tissue in our limbs can be stored under the skin (subcutaneous), on the surface of muscles (subfascial) and inside the muscles (intramuscular). Both diets resulted in a similar reduction in subcutaneous fat. However, only the vegetarian diet reduced subfascial fat, and was far more effective in reducing the amount of intramuscular fat. Why is this important? Subfascial fat is associated with insulin resistance in type II diabetes, so reducing it could benefit sugar metabolism in ways that "regular" weight loss cannot. Reducing intramuscular fat could also help to improve muscle strength and mobility, which is particularly important in older people.

But is a vegetarian diet beneficial for everyone all the time, especially in the case of antiaging and longevity? There is conflicting evidence. Research does show that being vegetarian does significantly reduce heart attack risk in under-65s by 45%, but this drops to only an 8% reduction after 80. Some studies do not show that vegetarians live longer than meat eaters, but two studies on people who rarely eat meat found an average life extension of 3.6 years. Another on Seventh-Day Adventists found a lifespan increase of about 7 years in men and 4 years in women. However, other research has found that vegetarians are very low in a nutrient called carnosine. Carnosine plays a key role in reducing the harmful glycation reactions which are known to be responsible for so much of aging. But how to the animals that give us carnosine through food obtain it themselves? Carnosine is made of the amino acids beta-alanine and L-histidine, and research on older adults (55-92) does show that beta-alanine supplementation improves physical working capacity. Additionally, sprint training increases the level of carnosine in muscle, because just like herbivorous animals, we make carnosine ourselves. In conclusion, yes, vegetarian diets are best for at least some people, and there are ways to make up for what you miss out on with a meat-free diet.

Thursday, 22 June 2017

Too Many Are Unaware of the Obesity-Cancer Link

Prevention skeptics would tell you that if cancer was preventable and we knew what caused it, then no one would be developing it. This is, however, not the case, and it isn't just about people continuing to smoke despite knowing the risks. After smoking, obesity is the second most common cause of cancer, but the message doesn't seem to be getting through to people! Cancer Research UK has recently found that 75% of people don't know that obesity contributes to several types of cancer, including breast cancer. Men and members of lower-income families are less likely to be aware of the connection. In the UK, one quarter of people are obese, even though it is now common knowledge that staying active and eating a healthy diet, high in vegetables and fruit, can prevent and reverse obesity. We are told this since childhood, but obesity rates haven't fallen as much as they should. Many naturopaths point out that diet and exercise aren't always enough because of environmental toxins, but is there any evidence to back this up?

Even makeup may contain phthalates.
Source: Tiffany Bailey (CC: 2.0)
Actually, both human and animal studies have found that environmental toxins, such as BPA, can dramatically raise the risk of becoming obese. After animal studies found that BPA could raise the risk of being overweight or obese, researchers set out to see if it had the same effect in humans. Over 1300 boys and girls from grades 4-12 at several Shanghai schools had their urine levels of BPA tested and compared to their body weight. Girls aged 9-12 with a higher than average level of BPA (over 2 micrograms/litre) had twice the risk of having their body weight in the top 10th percentile. If their BPA levels were over 10 micrograms/litre, they had five times the risk of obesity. Thirty-six percent of the girls with above-average BPA levels were overweight or obese, compared to 21% with below-average levels. Boys, however, did not seem to be affected by BPA, most likely because it is oestrogenic. The authors then suggested that BPA could increase weight gain and accelerate pubertal development for girls during their pre-teen years. BPA also reduces adiponectin, a hormone that increases insulin sensitivity, along with other negative effects on the pancreas, thyroid hormone pathways and brain function. All of this may worsen the severity of food cravings and reduce the energy and motivation needed to get active. To minimise your exposure to BPA, use plastic and cans as little as possible for food preparation and storage; and use plastic in general as little as possible too.

Besides BPA, another hormone-disrupting class of chemical called phthalates has also been shown to increase obesity. These are found in personal care and cosmetic products; plastics and even in medication and supplement coatings. While phthalate exposure is near universal, one study has shown that children with the highest levels of DEHP, one of the phthalates, had five times the risk of obesity compared to children with the lowest levels! Together with BPA and other hormone disrupting chemicals, this may help to explain why the rate of childhood obesity in the USA has grown from 7% in 1980, to over 40% in 2008, with 15% of 6-19 year olds classed as "obese". In conclusion, if diet and exercise aren't shifting unwanted weight in you or your child, it may be time to look at what chemicals you are being exposed to.

Wednesday, 21 June 2017

In Defense of Coconut Oil

If you read the mainstream health news for whatever reason, by now you would have seen the USA Today article advising Americans to stop using coconut oil and replace it with omega-6 rich vegetable oils. Of course, for this article, based on an American Heart Association statement, to be true, it must be assumed that saturated fat is the enemy and inflammation isn't the key driver of health problems such as cardiovascular disease. But as this is not the 1980s anymore, we can't assume this to be true.

So many uses! Source: Crisco 1492 (CC 3.0)
High consumption of omega-6 fatty acids, and a low intake of omega-3 fats, can contribute to conditions such as cardiovascular disease, cancer and neurodegenerative diseases. Cooking with so-called "heart healthy" vegetable oils such as canola or safflower oil raises your omega-6:3 ratio. While we need both omega-6 and -3 fatty acids, their ratio should be, according to different sources, anywhere from 5:1 to 1:1, but most of us consume far too much omega-6 and too little omega-3. These fatty acids are used to make a type of signalling molecule known as eicosanoids. Omega-6 fats are converted to pro-inflammatory prostaglandins and leukotrienes, which are used in immune responses, by the enzymes cyclo-oxygenase and lipo-oxygenase. These enzymes also convert omega-3 fats to anti-inflammatory prostaglandins and leukotrienes. Why am I telling you this technical information? Many common painkillers work by suppressing cyclo-oxygenase, even though it isn't always the real enemy, too many pro-inflammatory fats often are. Research has even found that supplementation with DHA, an omega-3 fatty acid, can prolong remission and reduce symptoms of some autoimmune diseases. It can also improve nerve cell communication and inhibit neuroinflammation.

However, the USA Today article ignores all of this, instead focusing on the possibility that it could raise LDL ("bad") cholesterol. But the most recent Dietary Guidelines Advisory Committee removed cholesterol as a cause for concern, stating that there is "no appreciable relationship between dietary cholesterol and serum cholesterol or clinical cardiovascular events in general populations”. Many studies have found that low cholesterol may in fact be associated with a higher risk of dementia, suicide, homicide, accidental death and depression!

Coconut oil is not only safe, it also could have health benefits! In a small study of 20 people with Alzheimer's disease or mild cognitive impairment, supplementation with medium-chain triglycerides (MCTs), which coconut oil is rich in, resulted in improved cognitive performance in some patients. Only patients who had a 4- APOE gene saw improvement in their condition. Higher levels of ketones were associated with better performance in paragraph recall with MCT use relative to placebo. Additionally, in another study, taking coconut oil helped patients to achieve reductions in weight, BMI, waist and neck circumference, and diastolic blood pressure. Coconut oil also gave them higher HDL ("good") cholesterol. All patients had coronary artery disease and high blood pressure, and most of them were "elderly" with an average age of 62. Looking at newer and more nuanced evidence, there is no reason to throw out your coconut oil! It's vegetable oils that belong in the bin.

Tuesday, 20 June 2017

Old Age Isn't Old Age Anymore

This year, the oldest of the Baby Boomers are turning 70. But the eighth decade of life isn't what it used to be, with celebrities such as Cher (who also turns 70 this year) no longer holding a monopoly over looking and acting younger. Life expectancy is still rising, and the UK's Oxford Institute of Population Aging is recommending that people in their 70s and 80s be called "active adults" instead of "old". Even the Daily Mail has added to the discussion, with a few writers who are, well, rewriting what it means to be over 70.

She may be 67 here, but has no monopoly
on retaining youthfulness.
Source: David Carroll (CC 2.0)
First up is Angela Neustatter, who at 73 looks years younger than you'd expect. She attributes her youthfulness to yoga, Pilates, a house full of stairs, sex and stepping back from emotional conflict. Angela does and wears what she wants, even mini skirts and leggings! Lesley Pearce also appears to be in her 50s at the age of 72. Her "normal" involves parties, swimming and scrambling around her cliff-top garden. Jan Leeming is still a BBC newsreader at the age of 75. As part of the first generation of women to have lifelong careers, she doesn't see the point of retiring or giving up travel or physical activity. Jo Foley is also very grateful for a life of freedom, so unlike her mother's generation. She describes the new and improved "normal" as: "In our 70s we shop at Zara, drink pisco sours, take slow boats along the Mekong and talk to ourselves without contradiction." Jo then adds, "Did we ever think to thank our parents?", referring to the restricted life of marriage, children, staying home and growing old that she saw in previous generations.

Older age groups growing younger are nothing new, however. Dr Martin Connolly, Freemason's Professor of Geriatric Medicine at Auckland University, says that 90-somethings today are the same in terms of health and fitness as 70-somethings at the end of World War One. He describes meeting someone over 90 as "rare" thirty years ago, but common now. And despite his position, he struggles to pinpoint the age of someone over 90 by looking at them, even though he has an easy time of doing the same for someone under 90. This may be because researchers have found that aging appears to stop at around 90 in humans (with a range of 80-100), and at different ages in other animals. It's hard to get your head around, but we do have our own mechanisms of fighting key drivers of aging such as oxidative stress and inflammation, and the aim of this research is to keep those mechanisms strong. Overall, these days, we don't have as much to fear or put up with as we once thought, as times are changing in ways we didn't previously expect.

Friday, 16 June 2017

Horse and Music Therapy May Help Stroke Patients

Conventional wisdom would tell you that stroke patients only have a limited time and capacity to recover lost physical and mental functions. Now, a new study suggests that horseback riding and music and rhythm therapy, which are not typically used in stroke recovery, may improve outcomes even in people who are years post-event.

"Normal" methods in stroke recovery start as soon as the patient is awake and stable. What this involves depends on the damage: speech and language therapy if those centres of the brain were affected; physical therapy if limb function was damaged; or help in getting back to work, among other things. As stroke survivors usually do not continue rehab for too long, it isn't clear whether or not the same approaches will work for later stages of recovery. The "normal" opinion is that the potential for recovery is limited. Fortunately for too many, researchers are increasingly looking at "late-phase" recovery, as knowledge of neuroplasticity grows. Neuroplasticity gives us the ability to recover from injury by working around the damage and even growing new neurons (see: The Brain That Changes Itself).

Source: David Blaikie (CC 2.0)
For this study, conducted in Sweden, researchers randomly assigned 123 stroke survivors to horseback riding, music and rhythm therapy, or conventional care. Patients in both treatment groups met with their therapists twice a week for 12 weeks. Although it was only for three months, after six months, patients lucky enough to be in the horse riding or music therapy groups showed better balance and mobility than the control group. They were also more likely to rate their recovery as having progressed, with 56% and 43% noticing improvement respectively, compared to only 22%. Despite this being a small study, the results are promising, but music therapy was deemed more feasible because of the setting and cost required for horse riding. Both of them stimulate the body and mind in ways that can aid neuroplasticity. This form of music therapy requires participants to move their hands and feet in patterns based on cues in the music and visual instruction. Horse riding simulates normal human walking, without having to move yourself. While music therapy was seen as more widely available, regions such as Queensland in Australia already have programs such as Riding for the Disabled. Many people who join this program see improved physical function, including better reflexes, increased range of motion and stretching of spastic or overly tight muscles. And unlike traditional therapy, it's fun!

This is not the first study to show functional improvement with horse riding after stroke. A smaller one, published in 2015, assigned ten patients to 30 minutes of horse riding a day, 5 days a week, for six weeks (the other ten were the control group). The group who got to ride horses showed significant improvement in gait, balance and activities of daily living, both compared to their abilities before and to the control group. While these were relatively small gains, the trial was only for six weeks. Overall, research may be in its early stages, but horse riding could be a great new hobby and therapy for stroke survivors, as it can do more than just standard therapy alone.

Thursday, 15 June 2017

Can We Enhance Growth Hormone Naturally?

Antiaging and longevity circles have known for many years that a decline in human growth hormone (HGH) levels play a key role in the aging process. Younger people have abundant levels of HGH, allowing for a youthful metabolism and body composition. However, reaching "middle age" results in a decline of HGH and other hormones, causing muscle loss, fat gain and many other problems. In men at least, every seven years after the age of 25 brings a 50% drop in the size of HGH's pulsed release. So it should be a simple matter of replacing lost HGH, right? Well, one study in men over 60 did find that 6 months of HGH injections had effects on lean body mass and fat tissue that were equivalent to reversing 10-20 years of aging, but growth hormone replacement is still controversial and not always available. Fortunately, there are relatively simple ways to naturally increase production of our own HGH, which are also much cheaper.

So, what is HGH made of? Like many other things produced by the body, it is made of amino acids, the building blocks of protein. The most important amino acids for HGH are glutamine, arginine, ornithine and glycine. Glutamine is the most abundant amino acid in the body, and even consuming a relatively small amount of 2 grams (2,000mg) has been shown to increase blood levels of HGH. It has even been found to help protect muscle mass in patients vulnerable to losing it after inactivity following surgery. Therefore, protein supplementation could save a lot of time, money and inconvenience to people recovering from surgery. Arginine is also able to increase HGH release at rest, with its effects even greater when combined with exercise. Ornithine alpha-ketoglutarate is both tissue-building and may boost HGH secretion. Other research shows that combining arginine and ornithine aids the benefits of strength training by increasing lean body mass and strength. We should be consuming protein soon after exercise anyway. Glycine not only improves sleep, but a supplement mix of glutamine, glycine and niacin (vitamin B3) was found to significantly boost HGH levels in middle-aged and older men and women. Those who also responded with an increase in IGF-1 reported improved energy and memory.

The amino acids most important to HGH production are best when combined with exercise, because of their other tissue-building effects, but exercise alone is another way to increase HGH. One study compared the effects of exercise and passive standing on HGH, with both of these split into groups where volunteers were exposed to either 18 or 33 degree temperatures. All groups experienced a significant increase in HGH, but the strongest effects were seen in the exercise group exposed to higher temperatures.

Wednesday, 14 June 2017

Terminally Ill Toddler May Be Saved By New Treatment

Most of us take our lives and those of our children for granted, but for an unfortunate minority, rare genetic diseases don't just threaten to steal lives away, they are serious enough to follow through with it. This is the case for one such genetic disease called spinal muscular atrophy (SMA), but a recently released drug holds promise as its first known treatment.

Unfortunately, not everything is going smoothly. Some children, such as toddler William Storr, have been denied access as not all hospitals in the UK are providing it. His version of the disease is so severe that 95% of children like him do not live to see their second birthday. He can only move his hands and toes, cannot swallow and cannot breathe properly. While clinicians, charities and patient groups are calling on the NHS to make the drug, known as Spinraza, available to all people with SMA, the NHS claims there are a lack of staff and beds (even though SMA is rare). Until NICE, another UK health organisation, approves the drug themselves, Spinraza is only available through an expanded access program run by the pharmaceutical company that produces it. Fortunately, the Sheffield Children's Hospital is opening a discussion with the Storr family and six others whose children need the treatment, as it is likely to be available there soon.

Spinraza.
So what is all the fuss about...does it really work? Spinraza is a biologic drug, designed to increase expression of another gene that produces the "survival motor neuron" protein. Without it, motor neurons die off and victims lose muscle function. Multiple clinical trials have shown that Spinraza is able to bring about neurological improvements in the majority of participants receiving it. Most children were also able to meet the developmental milestones that almost all of us take for granted. Survival rates, of course, improved too.

Natural therapies do not exist for spinal muscular atrophy, as there are only a very small number of in vitro (test tube) studies showing an effect of nutrients on the remaining spinal motor neuron protein gene, SMN-2 (SMN-1 is the gene lost in SMA). In one of these, curcumin (from turmeric), EGCG (from green tea) and resveratrol (from red grapes and Japanese knotweed) were able to increase the rate of SMN-2 producing the full-length, functional SMN proteins, as it usually makes shorter, useless ones. This of course meant that cells of patients with SMA began to contain more of the full SMN proteins, and it may mean that these polyphenols could be a useful adjunct to Spinraza. The drug should be available to anyone who needs it, as should anything that is the only treatment for a disease this serious.

Tuesday, 13 June 2017

How Music May Help People with Dementia

Natural therapies aren't just about nutritional and herbal medicine, usually with some lifestyle advice added in. There are also many psychological and energetic healing modalities, each with their own benefits that food, nutrients and herbs may not be able to achieve alone. Music is one of them, as there is something about it that can light up various areas of the brain, including the nucleus accumbens (which releases dopamine), the amygdala (which processes emotion) and the prefrontal cortex (which makes decision-making possible). Because of all of these effects, researchers have been looking into music as a way to give at least some relief to people suffering from dementia.

Some examples of how music can benefit people with dementia were documented in the 2014 documentary Alive Inside, but researchers wanted to evaluate this in a scientific manner. They then decided to implement a "Music and Memory" program in 98 nursing homes, and compare the results to 98 nursing homes used as a control group. The endpoints they compared included the discontinuation of antipsychotic and antianxiety medication (if used), reductions in disruptive behaviour and improvements in mood. Over six months, dementia patients who got to listen to music personalised to their tastes had a 20% chance of discontinuing antipsychotics, compared to 17.6%. 57% had reduced behavioural problems, compared to 51%. Music can also bring back lost memories, especially if it is tied to their past.

Singing bowls. Source
Other research has found healing effects of sound too, this time with singing bowl sound therapy. An observational study on 62 people found that, using the POMS scale (Profile of Mood States), sound therapy had significant effects on tension, anger, confusion, fatigue and vigour. Using the HADS (Hospital Anxiety and Depression Scale), depression and anxiety levels also dropped considerably. Spiritual wellbeing also increased. In another study described by the authors, which was a randomised cross-over trial, use of a singing bowl was more effective than silence alone in reducing blood pressure and heart rate before a guided visualisation. Yet another trial examined the effects of a crystal singing bowl on the body's electrodermal responses. Forty acupuncture meridian points on the patients' left hands and right feet showed increases and decreases respectively in electrical impulses. That study showed this effect with both "toning", where a Marcel Vogel crystal was held to chakra points on the subject's back, and playing a crystal bowl tuned to the note "F", which corresponds to the heart chakra. Everyone acted as their own control; while some people would prefer a separate placebo group, this could have an advantage as we are all individuals.

While it may be too new of a concept to be published in high-quality journals, a more informal trial conducted in Western Australia suggests that sound therapy with singing bowls may specifically help patients with dementia. The main endpoint was reductions in "agitation", involving aggression, verbal agitation (such as screaming and repetitive sentences) and physical non-aggressive behaviour (such as taking clothes off and handling objects inappropriately). After some time with recorded sound therapy, residents were more likely to be classed as non-agitated across all three categories. Case studies described some residents as having improved appetite and sleep, being more active and alert, and better verbal ability. From the findings so far, sound therapy looks like something that should be far more recognised, and more research is needed to both quantify and refine its effects.

Friday, 9 June 2017

Switzerland May Ban Aluminium in Deodorants

If you've been to Switzerland, you know that it is an absolutely beautiful country, especially if you are into snow- or lake-related sports. Now, we may have another reason to love them: on the 5th of May, their National Council voted to approve a bill instructing their Federal Council to ban the use of aluminium in deodorants, based on research that the mineral could cause cancer.

Switzerland. Source: Andrew Bossi (CC: 2.5)
One of the studies that this proposed law is based on suggests a link between aluminium and breast cancer. First, the Swiss scientists exposed normal human breast cells to aluminium, and over time exposure caused some to turn into cancer cells. Then, injecting small amounts of aluminium into mice had the same effect: the mice developed tumours, which grew and spread to other areas of the body. Their earlier research was met with scepticism, but increasing evidence showing that aluminium could be a carcinogen meant that follow-up studies were easier to publish. While the study does not completely confirm that it causes cancer, co-author Andre-Pascal Sappino still stated that "I think we should avoid all deodorants containing aluminium salts". He draws an analogy between aluminium and asbestos, as they are both cheap and have attractive industrial potential, and despite all of the research condemning asbestos as a dangerous carcinogen, it took 50 years for the substance to be banned. Fortunately, it is now banned in Switzerland and across the European Union, as well as other countries like Australia. But this doesn't change the fact that so many people died of cancer before this link was confirmed and asbestos was banned. Also like asbestos, aluminium does not cause genetic mutations in bacteria, but they do in animals. And like the tobacco industry, the oncologists who performed this research now expect backlash from the cosmetics industry, who are likely to say that proof in humans is lacking.

Another recent study adds further weight to the link between aluminium and breast cancer. Partly because of the use of deodorants, aluminium has been found in higher concentrations in the breast than in the blood. Aluminium can cause instability in the genome, inappropriate cell division, and increase migration and invasion of already-established breast cancer cells. Additionally, it can act like an oestrogen, despite being a mineral. The most common benign disorder of the breast is gross cystic breast disease, and there is even evidence that aluminium could cause this too. To make things even worse, aluminium has been implicated in Alzheimer's disease too. The brain tissue of people with Alzheimer's disease generally contains a much higher concentration of aluminium than that of age-matched controls. In people with early-onset Alzheimer's disease, the concentration is even higher.

As you could tell, the Switzerland love doesn't stop there. A recent referendum (their democracy is also very well-developed) voted in favour of phasing out nuclear power, which will be replaced by clean renewable energy. No new licenses will be given to nuclear plants, and when the existing ones reach the end of their lifespan, they will not be replaced. Nuclear power generates just over a third of Switzerland's electricity, and clean renewables generate almost two-thirds, so while there is a lot of work to do, their goal is achievable. Overall, there is hope for a world where we can live longer, healthier lives without this current cancer epidemic, but often we have to look to other nations for inspiration.

Thursday, 8 June 2017

Fight Back Against Air Pollution!

When you do "everything right" but still manage to develop a life-threatening chronic illness, the question is: why? Well, the truth is that we live in a toxic world, with over 80,000 different synthetic chemicals having been produced over the last 70 years. Of these, over 4 billion pounds (2 billion kilograms) are released into the world every year. Many are known carcinogens, and most have not been fully evaluated for their effects on human health, especially not in combination with each other. However, we do know now that air pollution alone is responsible for around 200,000 "premature" deaths in the USA alone each year. Greater exposure to air pollution is associated with higher mortality rates and a higher risk of cardiovascular and respiratory illnesses. New research also links air pollution to impaired glucose tolerance, and blood vessel damage in people as young as 23! "Oh, they're just starting to age" is merely an excuse.

The good news is that things are starting to improve. Renewable energy capacity is reaching record highs, in both new capacity and percentage of total capacity. Plummeting costs and increasing storage availability are contributing to clean energy becoming the new normal. But conversion to 100% clean energy will take years, most likely a few decades, so what can we do in the meantime? One set of nutrients that may protect against a particularly dangerous effect of air pollution - decreased heart rate variability - is the B vitamins. A study on the effects of folate, vitamin B6 and vitamin B12 found that people with lower intake of these showed reduced HR variability after exposure to higher levels of particulate matter, a nasty type of air pollution. A high daily intake of these vitamins prevented this effect. Another way to protect yourself against air pollution is vitamins C and E. Research on people who work at or live near coal power plants found that supplementation of 500mg of vitamin C and 800mg of vitamin E reversed the extra oxidative stress caused by their living or working conditions. Before supplementation, levels of free radicals were higher, antioxidant levels were lower, and their bodies' own antioxidant enzymes were working much harder to try to prevent damage.

Besides vitamins, fish and olive oil could also protect us against air pollution. Researchers studied elderly volunteers to determine if omega-3 fatty acids from fish oil could have an effect on the damage caused by particulate matter. They found that taking 2 grams of fish oil every day for 4 months was able to significantly raise their antioxidant defences - levels of superoxide dismutase rose by 49%, and glutathione rose by 62%. These are antioxidants that our bodies produce themselves. The rate of lipoperoxidation, which means oxidative damage to fatty tissue, fell by 72%. This could mean that the fish oil was protecting them against more than just the air pollution. In a study of people deliberately exposed to air pollutants, supplementation with olive oil was able to preserve their blood vessel function. In fact, it improved their blood and blood vessel functioning. Of course, the best way to prevent disease and deaths from air pollution is to not generate it in the first place, but this will take many years.

Wednesday, 7 June 2017

Gut Bacteria Diversity and Longevity

By now, it's common knowledge that our gut bacteria play a big role in the state of our health. Many of us know now that a healthy composition of gut bacteria can improve our digestion, prevent embarrassing symptoms related to poor digestion and even prevent infections such as colds and flu. But did you know that they can also affect aging and longevity?

Research shows that as we get older, both our gut bacteria counts and the number of species declines. This is not just an inconsequential symptom, as a decline in microbiome (the "ecosystem" of bacteria inside our digestive system) quality can raise the risk of digestive, immune and even neurological conditions. You may also not know that there are now many people over the age of 100 (known as "centenarians") who are healthy and vital enough to live independently. Studies on them have shown too that independent centenarians have a higher diversity in their gut microbiomes than centenarians living in aged care homes or other assisted living facilities. Of course, worse off still are those who haven't lived to this age.

Kimchi. Source: Alan Chan (CC 2.0)
So how can we increase the diversity of our microbiome? One way is to become more in touch with nature, as urban environments cut off our exposure to many beneficial, commensal microbes. This may be a reason why "green" and "blue" spaces are linked with improved mental and cardiovascular health, as well as reduced mortality rates. When you are spending time inside, indoor plants can make your environment much healthier.

Traditional fermented foods are another way to improve our intestinal microbiome. In a small trial, prediabetic patients were instructed to consume either 1-day or 10-day fermented kimchi, which is a traditional Korean food. Both types of kimchi significantly reduced the average body weight, waist circumference and BMI. However, the 10-day fermented kimchi also decreased insulin resistance, and of course, increased insulin sensitivity. Only 9.5% of people eating 1-day old kimchi saw improved glucose tolerance, compared to 33.3% in the 10-day fermented group. Blood pressure also dropped significantly in the 10-day group, which has its own benefits. More general dietary advice is to eat a wide variety of foods; as different bacteria have different food sources, this can boost the diversity of your microbiome. However, it is important to avoid the foods you are intolerant or allergic to, and to get tested if you suspect any sensitivity. Gut inflammation can disrupt the microbiome and its communication with the immune system. Overall, you don't have to rely on "luck" or "fate" to live a long, healthy life. The secrets to longevity are hidden in plain sight.

Friday, 2 June 2017

Could Resveratrol Help Treat Alzheimer's Disease?

Alzheimer's Disease and other dementias are perhaps the worst kind of age-related disease there is. They affect everything about a person, not just the physical body, so anything that may help to slow or reverse these problems is definitely worth consideration. One of these interventions could be resveratrol, a much-studied natural substance with many potential antiaging effects.

For this study, 119 patients with mild-moderate Alzheimer's Disease were analysed. Of these, 19 took 1 gram of resveratrol twice daily, and 19 took a placebo, both for 52 weeks (one year). Resveratrol's antiaging effects are largely due to its ability to activate the SIRT1 gene. After 52 weeks, the treatment group showed signs that their levels of neuro-inflammation had fallen, and their immune systems were working more effectively. Resveratrol also slowed the decline in mini-mental status exam (MMSE) scores, as well as activities of daily living (ADL) scores. The decline in MMSE scores was not seen as statistically significant, meaning that it may not have truly deteriorated. The decline in ADL scores was half that of the placebo group. Additionally, the "normal" progression of Alzheimer's involves dysfunction and senescence of immune cells in the central nervous system. This impairs their ability to take out the cellular and interstitial "garbage", which has serious implications for neurological health.

Red grapes are the top food source of resveratrol,
though therapeutic doses call for supplementation.
Resveratrol is known as a pharmacological mimic of calorie restriction, which is the act of consuming two-thirds of the normal energy requirements. Research has shown that this can prevent or postpone many of the complications of aging, which is why many people have found health benefits from various fasting techniques, e.g. the 5:2 diet or confining food intake to 8-12 hours each day. On the other hand, diabetes and obesity increase the risk of problems such as Alzheimer's Disease. Activation of sirtuin genes, especially SIRT1, appears to be one mechanism behind the benefits of calorie restriction.

Actually, calorie restriction itself has been found to impact neurodegenerative diseases and other health problems. This is partly because many of these involve chronic inflammation, and research has shown that alternate-day fasting can reduce levels of inflammatory markers. This has been linked with reductions in the symptoms of asthma and rheumatoid arthritis, and even improved functional outcomes in a mouse model of stroke. Fasting may even have beneficial effects on genetic disorders. An animal study on mice with Charcot-Marie-Tooth Type 1A found that intermittent fasting could also improve motor performance and reduce the demyelination that is responsible for functional decline. Without myelin, our nerve cells cannot transmit signals as effectively. The mechanism behind this was improved autophagy, which clears out garbage in the cells, and in this case it included inappropriate aggregates of myelin protein. Both Parkinson's and Alzheimer's diseases also involve inappropriate protein aggregation, in PD alpha-synuclein is involved, and in AD we see amyloid-beta and tau proteins causing trouble. The only problem with these fasting techniques is that, although they are not constant, we have been raised to think that non-pregnant adults must be constantly eating throughout the day, and that any food restriction is a "punishment". But with all of the research on intermittent fasting techniques, which would you prefer (as long as you are medically able to fast, and need to), a relatively small amount of pleasure and poor health, or some discipline in exchange for a great life?

Wednesday, 31 May 2017

Aging is Almost Officially a Disease

Finally! After all of these years, aging itself is on its way to be officially classified as a disease. Of course, it's taken decades of improving life expectancy and survival rates due to better living standards and lifestyles, but we're here! This means that antiaging will be taken more seriously by the health industry and society as a whole, including insurance companies.

So, what happened exactly? Well, two years ago, researchers managed to convince the US FDA to approve a human lifespan study of metformin, which is currently used for blood sugar control. If all goes well, it will be the first drug approved specifically to treat aging. The study, known as the TAME Study (Targeting Aging With Metformin) started up in 2016, aiming to enrol 3,000 people aged 70-80 and study the effects of metformin over 5-7 years. Everyone must be at risk of or have one or more of the following: cancer, heart disease or dementia. If metformin can delay or prevent these and delay death, the next step is to test it in younger people.

But why metformin? High blood sugar and insulin resistance are key factors in aging and other complex, chronic illnesses, such as cardiovascular disease and cancer. But this is not the only way that metformin could fight aging. Metformin works by acting on an enzyme called AMPK (adenosine monophosphate-activated protein kinase), which regulates how cells process energy. AMPK boosts metabolism, which may aid weight loss by burning more sugar and fat; improves blood flow and body composition; aids cell detoxification and renewal; and has antioxidant, anti-inflammatory effects. On the other hand, unaddressed aging results in slowing metabolism and weight gain; muscle loss; poor circulation and detoxification and a vicious cycle of inflammation.

Gynostemma pentaphyllum. Source: Lioman
Is metformin really the best solution to aging? Unfortunately no. Aging is a complex disease involving chronic inflammation, so health and longevity promoting strategies that target the whole person are likely to be far more effective. As it is multifactorial, focusing on one aspect of it is probably not the best strategy, as other complex, chronic diseases do not respond to this method. Metformin is not without side effects, either. It has a black box warning for the rare-but-dangerous side effect of lactic acidosis, which is especially problematic in reduced kidney function. It may also be pro-inflammatory and increase production of beta-amyloid protein, which gets tangled in brain tissue as it accumulates and causes the symptoms of Alzheimer's disease. If you want to use pharmaceutical drugs, aspirin is an anti-inflammatory AMPK activator.

So what can we do to fight aging? There are natural antiaging therapies that also activate AMPK, without the side effects. Intermittent fasting, where food intake is confined to 8-12 hours of the day, has been shown to promote longevity and fight age-related diseases. Exercise not only keeps the musculoskeletal and cardiovascular systems strong, but also activates AMPK, especially in HIIT. Cold water immersion, especially after exercise, also enhances AMPK. There are also herbal remedies that can activate AMPK, in particular Gynostemma pentaphyllum. A human study involving diabetic patients found that this herb reduced haemoglobin A1c ten-fold, which measures the rate of glycation (a very pro-aging process), decreased insulin resistance by three-fold and did not cause dangerously low blood sugar. It has been used as a pro-longevity herb in some Chinese circles for six hundred years, but only now do we know exactly how it works and how to best use it. While metformin may be a promising treatment for aging, there are natural alternatives that could be far superior.

Monday, 29 May 2017

Another Use for CoQ10: Diabetes

Coenzyme Q10 has long been known for its antiaging properties, especially in the cases of energy production and cardiovascular health. Now, it seems as though we have another use for the not-quite-a-vitamin, the prevention and mitigation of diabetes.

One little-publicised cause of diabetes may be the use of statins, marketed as "prevention" for cardiovascular events. Some statins, such as rosuvastatin, are linked with a 27% higher risk of type II diabetes! Two meta-analyses also found an elevated risk of diabetes, one with a 9% higher risk, and the other showing a 12% higher risk. This disproportionately affects the elderly, who are most likely to be prescribed statins.

So why do statins raise the risk of diabetes? Statins work by blocking an enzyme called HMG-CoA reductase, but this also blocks a precursor to coenzyme-Q10. Depletion of CoQ10 disrupts mitochondrial function, and besides affecting energy levels, this also has a negative impact on insulin signalling, which could lead to the blood glucose dysregulation known as diabetes. To make things even worse, lowering LDL cholesterol also reduces CoQ10 transport into cells, with the combination of these effects depleting CoQ10 by as much as 54%.

Even these could protect cardiovascular health
more than some drugs. Source: Evan Amos
This is why medical professionals now often recommend CoQ10 supplements to anyone taking statins. In fat cells exposed to statin drugs, the coenzyme can restore the normal glucose uptake mechanism that the drugs also disrupt. Additionally, CoQ10 has been found to reduce blood sugar and HbA1C levels in diabetic patients. Blood sugar tests only take a picture of how your glucose regulation is doing now, haemoglobin A1C gives an idea of your blood glucose regulation over the past four months, as it shows how much sugar has been tangled in the haemoglobin proteins. The root cause of many diabetes complications is loss of endothelial function (the lining of the blood vessels), which leads to poor blood flow and tissue destruction in parts of the body such as the eyes, kidneys and toes. Worse still, this can even affect the heart, causing something known as diabetic cardiomyopathy (heart muscle damage). Fortunately, supplementation with 200mg of CoQ10 has been found to significantly improve loss of endothelial function in diabetes, which may spare many from crippling complications.

But do we even need these CoQ10-depleting statins? Research has actually shown that statins may be more harmful than beneficial for the heart, even if there were no alternatives. Statins have been found to increase the risk of microalbuminuria, which is a known marker of blood vessel dysfunction. Other studies have found that some statins could worsen heart function, increase LDL oxidation (which is the cause of plaque!), cause heart failure and/or atrial fibrillation (a fluttering movement that does not pump blood!), reduce blood flow to the heart and weaken the heart muscle. The CoQ10 depletion may also be behind the increase in congestive heart failure in the USA. It is very fortunate that even "mere" diet advice can also protect against cardiovascular deaths, such as eating an apple every day - which may reduce LDL cholesterol by an impressive 40%! Overall, CoQ10 deficiency can be debilitating and even dangerous, but you don't have to suffer.

Saturday, 27 May 2017

Purpose and Longevity

We know instinctively that meaning and purpose are necessary in order to live a fulfilling life, with those of us in a career we love often held in high regard. And regardless of how passionate you may be about your career, we all need a hobby - an interest outside of work that we truly love to do. The benefits of purpose and hobbies, however, go beyond quality of life and into quantity as well.

Purpose can light up your life!
Japanese culture has a concept called ikigai, which roughly translates to "purpose in life". Ikigai has traditionally been associated with health and longevity, so a recent study on over four thousand adults set out to determine if this theory was true. All participants were over 65, with over 1800 identified as at high risk of death, over 1200 at high risk of losing ability to perform activities of daily living (ADLs), and over 1100 at risk of losing their ability to perform instrumental ADLs. Data from February 2011 to November 2014 was used, which can be a long time when it comes to age-related disability. Compared to people who had both hobbies and an ikigai, having neither of these was associated with double the risk of mortality, close to triple the risk of losing ADL abilities and almost double the risk of losing IADL abilities! This was adjusted for age, gender, BMI, income, alcohol and tobacco consumption, cognitive function, depression and number of chronic illnesses. Therefore, hobbies and ikigai were linked to increased longevity and healthy life expectancy in older adults.

This was not the only study that found a link between purpose in life and longevity. An American study on 6000 adults, with a 14-year follow-up time, found that people who initially reported a strong purpose in life had a 15% lower risk of dying. In a NIH-funded study that followed people aged from 65 to 92 for 11 years, those who described clear goals and purpose lived both longer and better than those who did not. In fact, other "Blue Zone" cultures (areas with a high prevalence of centenarians) besides the Okinawans of Japan value purpose, with the Nicoyan (Costa Rica) people calling it plan de vida.

So how can you find your own ikigai, if you haven't already? A great way to start is by doing an internal inventory. Take a piece of paper, and for 20-30 minutes think of all your ideals, principles, standards and morals, then think of your physical, mental and emotional talents, strengths and abilities. It can take a while, maybe even a couple of attempts, to get an idea of what you really want, but you know you're getting close if anything brings out a strong emotional reaction. And then...put your skills into action! It's also important to build relationships with people who can help you achieve your goals. Overall, longevity is for everyone, and it turns out that some of the best ways to extend your life also improve its quality.

Friday, 19 May 2017

Could Herbal Birth Control Be Available Soon?

Natural systems of medicine, such as European naturopathy, traditional Chinese medicine and Ayurveda, are very popular among couples struggling with infertility. But what about those of us who don't want children? Conventional methods of birth control include hormonal drugs, which often cause nasty side effects, implants and surgery - but what if there was a more natural approach, one with side benefits?

It turns out that this could become a possibility. Centuries before the oral contraceptive pill was approved in 1960, women tried all sorts of methods to prevent unwanted pregnancy. Staunch supporters of modern medicine (only) like to point and laugh at use of crocodile dung and cat testicles, but there were much more pleasant remedies around. One of these is the thunder god vine, also known as Tripterygium wilfordii in scientific circles. In a research article published on the 15th of May, 2017, scientists at the University of California describe exactly how two phytochemicals present in the medicinal herb can prevent fertilisation.

Cycle tracking beads. Source: Dellex.
When a sperm cell travels through the female reproductive system, its flagellum (whip-like tail) lets it swim forward. If it finds an egg, this flagellum must go into a "drilling" mode to allow it to penetrate through the egg's jelly lining. The drilling mode is impossible without a reaction between progesterone and a protein that sperm produce called ABHD2. Pristimerin and lupeol, two phytochemicals found in thunder god vine, were able to block this reaction. Only a tiny amount of these were required to prevent fertilisation - about 10 times less than the amount of levonorgestrel in Plan B. This also explains why infertility is often reported after the herb's more common use as a natural anti-inflammatory for problems such as arthritis. In the future, these, either isolated or maybe as part of a standardised herbal extract, could become a low-dose, safer form of birth control for both genders. Unfortunately, human clinical trials are years away.

There are also other forms of "natural family planning", such as the Billings ovulation method, which are free of side effects, but may be less reliable. In a small study, 15 Turkish women monitored their fertility across 30 menstrual cycles using both the Billings method and urinary levels of luteinising hormone (LH), which spikes during ovulation. The Billings method detected a potentially fertile period of 10 days, with a "peak" in the cervical mucus sign on day 13 (as an average, day 13.65). The surge of LH that accompanies ovulation also peaked on day 13 (as an average, day 13.65), and lasted for five days. This association was deemed significant, and it was concluded that women can use this method effectively. However, it is a small study, and every woman is different. According to the World Health Organisation (1981, sourced from Wikipedia), this method is at least 97% effective with "perfect use", and 77-99% effective with "typical use". In other words, it seems best to stick to the Billings method's precise rules, and probably use a condom as well. So, in conclusion, you don't have to put up with birth control side effects just because you were born as an opposite sex-attracted woman. However, you do need the correct training to use natural family planning methods, and will probably have to wait several years for proven herbal methods.  This article is not intended to be birth control training or advice, it is just for general information.