Of course, supplementation of carnosine can also be effective, including in the case of congestive heart failure (CHF). Fifty patients received either 500mg of carnosine for six months or a placebo, in order to test differences in walking distance, quality of life and heart function. Patients getting carnosine saw significant improvements in the distance walked over six minutes, quality of life, peak exercise workload and oxygen levels. As for diabetes, a clinical trial of people at high risk for developing the disease found that although insulin resistance worsened in both groups, it increased 3.8 times more in the placebo group than in the carnosine group. Insulin secretion increased by 36% in the placebo group, but only by 3% in the carnosine group. Therefore, carnosine was able to mostly offset the effects of their current diet and lifestyle. The wide range of benefits that carnosine has demonstrated is because of the fact that high blood sugar and glycation affect every inch of our bodies. However, taking it is not an excuse to eat large amounts of sugary, processed foods all the time - but it can be a good prevention strategy for everyday, lower levels of glycation and during times when you do eat a lot of junk food, such as Halloween and Christmas.