Can We Enhance Growth Hormone Naturally?

Antiaging and longevity circles have known for many years that a decline in human growth hormone (HGH) levels play a key role in the aging process. Younger people have abundant levels of HGH, allowing for a youthful metabolism and body composition. However, reaching "middle age" results in a decline of HGH and other hormones, causing muscle loss, fat gain and many other problems. In men at least, every seven years after the age of 25 brings a 50% drop in the size of HGH's pulsed release. So it should be a simple matter of replacing lost HGH, right? Well, one study in men over 60 did find that 6 months of HGH injections had effects on lean body mass and fat tissue that were equivalent to reversing 10-20 years of aging, but growth hormone replacement is still controversial and not always available. Fortunately, there are relatively simple ways to naturally increase production of our own HGH, which are also much cheaper.

So, what is HGH made of? Like many other things produced by the body, it is made of amino acids, the building blocks of protein. The most important amino acids for HGH are glutamine, arginine, ornithine and glycine. Glutamine is the most abundant amino acid in the body, and even consuming a relatively small amount of 2 grams (2,000mg) has been shown to increase blood levels of HGH. It has even been found to help protect muscle mass in patients vulnerable to losing it after inactivity following surgery. Therefore, protein supplementation could save a lot of time, money and inconvenience to people recovering from surgery. Arginine is also able to increase HGH release at rest, with its effects even greater when combined with exercise. Ornithine alpha-ketoglutarate is both tissue-building and may boost HGH secretion. Other research shows that combining arginine and ornithine aids the benefits of strength training by increasing lean body mass and strength. We should be consuming protein soon after exercise anyway. Glycine not only improves sleep, but a supplement mix of glutamine, glycine and niacin (vitamin B3) was found to significantly boost HGH levels in middle-aged and older men and women. Those who also responded with an increase in IGF-1 reported improved energy and memory.

The amino acids most important to HGH production are best when combined with exercise, because of their other tissue-building effects, but exercise alone is another way to increase HGH. One study compared the effects of exercise and passive standing on HGH, with both of these split into groups where volunteers were exposed to either 18 or 33 degree temperatures. All groups experienced a significant increase in HGH, but the strongest effects were seen in the exercise group exposed to higher temperatures.

Terminally Ill Toddler May Be Saved By New Treatment

Most of us take our lives and those of our children for granted, but for an unfortunate minority, rare genetic diseases don't just threaten to steal lives away, they are serious enough to follow through with it. This is the case for one such genetic disease called spinal muscular atrophy (SMA), but a recently released drug holds promise as its first known treatment.

Unfortunately, not everything is going smoothly. Some children, such as toddler William Storr, have been denied access as not all hospitals in the UK are providing it. His version of the disease is so severe that 95% of children like him do not live to see their second birthday. He can only move his hands and toes, cannot swallow and cannot breathe properly. While clinicians, charities and patient groups are calling on the NHS to make the drug, known as Spinraza, available to all people with SMA, the NHS claims there are a lack of staff and beds (even though SMA is rare). Until NICE, another UK health organisation, approves the drug themselves, Spinraza is only available through an expanded access program run by the pharmaceutical company that produces it. Fortunately, the Sheffield Children's Hospital is opening a discussion with the Storr family and six others whose children need the treatment, as it is likely to be available there soon.

Spinraza.

So what is all the fuss about...does it really work? Spinraza is a biologic drug, designed to increase expression of another gene that produces the "survival motor neuron" protein. Without it, motor neurons die off and victims lose muscle function. Multiple clinical trials have shown that Spinraza is able to bring about neurological improvements in the majority of participants receiving it. Most children were also able to meet the developmental milestones that almost all of us take for granted. Survival rates, of course, improved too.

Natural therapies do not exist for spinal muscular atrophy, as there are only a very small number of in vitro (test tube) studies showing an effect of nutrients on the remaining spinal motor neuron protein gene, SMN-2 (SMN-1 is the gene lost in SMA). In one of these, curcumin (from turmeric), EGCG (from green tea) and resveratrol (from red grapes and Japanese knotweed) were able to increase the rate of SMN-2 producing the full-length, functional SMN proteins, as it usually makes shorter, useless ones. This of course meant that cells of patients with SMA began to contain more of the full SMN proteins, and it may mean that these polyphenols could be a useful adjunct to Spinraza. The drug should be available to anyone who needs it, as should anything that is the only treatment for a disease this serious.

How Music May Help People with Dementia

Natural therapies aren't just about nutritional and herbal medicine, usually with some lifestyle advice added in. There are also many psychological and energetic healing modalities, each with their own benefits that food, nutrients and herbs may not be able to achieve alone. Music is one of them, as there is something about it that can light up various areas of the brain, including the nucleus accumbens (which releases dopamine), the amygdala (which processes emotion) and the prefrontal cortex (which makes decision-making possible). Because of all of these effects, researchers have been looking into music as a way to give at least some relief to people suffering from dementia.

Some examples of how music can benefit people with dementia were documented in the 2014 documentary Alive Inside, but researchers wanted to evaluate this in a scientific manner. They then decided to implement a "Music and Memory" program in 98 nursing homes, and compare the results to 98 nursing homes used as a control group. The endpoints they compared included the discontinuation of antipsychotic and antianxiety medication (if used), reductions in disruptive behaviour and improvements in mood. Over six months, dementia patients who got to listen to music personalised to their tastes had a 20% chance of discontinuing antipsychotics, compared to 17.6%. 57% had reduced behavioural problems, compared to 51%. Music can also bring back lost memories, especially if it is tied to their past.

Singing bowls. Source

Other research has found healing effects of sound too, this time with singing bowl sound therapy. An observational study on 62 people found that, using the POMS scale (Profile of Mood States), sound therapy had significant effects on tension, anger, confusion, fatigue and vigour. Using the HADS (Hospital Anxiety and Depression Scale), depression and anxiety levels also dropped considerably. Spiritual wellbeing also increased. In another study described by the authors, which was a randomised cross-over trial, use of a singing bowl was more effective than silence alone in reducing blood pressure and heart rate before a guided visualisation. Yet another trial examined the effects of a crystal singing bowl on the body's electrodermal responses. Forty acupuncture meridian points on the patients' left hands and right feet showed increases and decreases respectively in electrical impulses. That study showed this effect with both "toning", where a Marcel Vogel crystal was held to chakra points on the subject's back, and playing a crystal bowl tuned to the note "F", which corresponds to the heart chakra. Everyone acted as their own control; while some people would prefer a separate placebo group, this could have an advantage as we are all individuals.

While it may be too new of a concept to be published in high-quality journals, a more informal trial conducted in Western Australia suggests that sound therapy with singing bowls may specifically help patients with dementia. The main endpoint was reductions in "agitation", involving aggression, verbal agitation (such as screaming and repetitive sentences) and physical non-aggressive behaviour (such as taking clothes off and handling objects inappropriately). After some time with recorded sound therapy, residents were more likely to be classed as non-agitated across all three categories. Case studies described some residents as having improved appetite and sleep, being more active and alert, and better verbal ability. From the findings so far, sound therapy looks like something that should be far more recognised, and more research is needed to both quantify and refine its effects.

Switzerland May Ban Aluminium in Deodorants

If you've been to Switzerland, you know that it is an absolutely beautiful country, especially if you are into snow- or lake-related sports. Now, we may have another reason to love them: on the 5th of May, their National Council voted to approve a bill instructing their Federal Council to ban the use of aluminium in deodorants, based on research that the mineral could cause cancer.

Switzerland. Source: Andrew Bossi (CC: 2.5)

One of the studies that this proposed law is based on suggests a link between aluminium and breast cancer. First, the Swiss scientists exposed normal human breast cells to aluminium, and over time exposure caused some to turn into cancer cells. Then, injecting small amounts of aluminium into mice had the same effect: the mice developed tumours, which grew and spread to other areas of the body. Their earlier research was met with scepticism, but increasing evidence showing that aluminium could be a carcinogen meant that follow-up studies were easier to publish. While the study does not completely confirm that it causes cancer, co-author Andre-Pascal Sappino still stated that "I think we should avoid all deodorants containing aluminium salts". He draws an analogy between aluminium and asbestos, as they are both cheap and have attractive industrial potential, and despite all of the research condemning asbestos as a dangerous carcinogen, it took 50 years for the substance to be banned. Fortunately, it is now banned in Switzerland and across the European Union, as well as other countries like Australia. But this doesn't change the fact that so many people died of cancer before this link was confirmed and asbestos was banned. Also like asbestos, aluminium does not cause genetic mutations in bacteria, but they do in animals. And like the tobacco industry, the oncologists who performed this research now expect backlash from the cosmetics industry, who are likely to say that proof in humans is lacking.

Another recent study adds further weight to the link between aluminium and breast cancer. Partly because of the use of deodorants, aluminium has been found in higher concentrations in the breast than in the blood. Aluminium can cause instability in the genome, inappropriate cell division, and increase migration and invasion of already-established breast cancer cells. Additionally, it can act like an oestrogen, despite being a mineral. The most common benign disorder of the breast is gross cystic breast disease, and there is even evidence that aluminium could cause this too. To make things even worse, aluminium has been implicated in Alzheimer's disease too. The brain tissue of people with Alzheimer's disease generally contains a much higher concentration of aluminium than that of age-matched controls. In people with early-onset Alzheimer's disease, the concentration is even higher.

As you could tell, the Switzerland love doesn't stop there. A recent referendum (their democracy is also very well-developed) voted in favour of phasing out nuclear power, which will be replaced by clean renewable energy. No new licenses will be given to nuclear plants, and when the existing ones reach the end of their lifespan, they will not be replaced. Nuclear power generates just over a third of Switzerland's electricity, and clean renewables generate almost two-thirds, so while there is a lot of work to do, their goal is achievable. Overall, there is hope for a world where we can live longer, healthier lives without this current cancer epidemic, but often we have to look to other nations for inspiration.

Fight Back Against Air Pollution!

When you do "everything right" but still manage to develop a life-threatening chronic illness, the question is: why? Well, the truth is that we live in a toxic world, with over 80,000 different synthetic chemicals having been produced over the last 70 years. Of these, over 4 billion pounds (2 billion kilograms) are released into the world every year. Many are known carcinogens, and most have not been fully evaluated for their effects on human health, especially not in combination with each other. However, we do know now that air pollution alone is responsible for around 200,000 "premature" deaths in the USA alone each year. Greater exposure to air pollution is associated with higher mortality rates and a higher risk of cardiovascular and respiratory illnesses. New research also links air pollution to impaired glucose tolerance, and blood vessel damage in people as young as 23! "Oh, they're just starting to age" is merely an excuse.

The good news is that things are starting to improve. Renewable energy capacity is reaching record highs, in both new capacity and percentage of total capacity. Plummeting costs and increasing storage availability are contributing to clean energy becoming the new normal. But conversion to 100% clean energy will take years, most likely a few decades, so what can we do in the meantime? One set of nutrients that may protect against a particularly dangerous effect of air pollution - decreased heart rate variability - is the B vitamins. A study on the effects of folate, vitamin B6 and vitamin B12 found that people with lower intake of these showed reduced HR variability after exposure to higher levels of particulate matter, a nasty type of air pollution. A high daily intake of these vitamins prevented this effect. Another way to protect yourself against air pollution is vitamins C and E. Research on people who work at or live near coal power plants found that supplementation of 500mg of vitamin C and 800mg of vitamin E reversed the extra oxidative stress caused by their living or working conditions. Before supplementation, levels of free radicals were higher, antioxidant levels were lower, and their bodies' own antioxidant enzymes were working much harder to try to prevent damage.

Besides vitamins, fish and olive oil could also protect us against air pollution. Researchers studied elderly volunteers to determine if omega-3 fatty acids from fish oil could have an effect on the damage caused by particulate matter. They found that taking 2 grams of fish oil every day for 4 months was able to significantly raise their antioxidant defences - levels of superoxide dismutase rose by 49%, and glutathione rose by 62%. These are antioxidants that our bodies produce themselves. The rate of lipoperoxidation, which means oxidative damage to fatty tissue, fell by 72%. This could mean that the fish oil was protecting them against more than just the air pollution. In a study of people deliberately exposed to air pollutants, supplementation with olive oil was able to preserve their blood vessel function. In fact, it improved their blood and blood vessel functioning. Of course, the best way to prevent disease and deaths from air pollution is to not generate it in the first place, but this will take many years.

Gut Bacteria Diversity and Longevity

By now, it's common knowledge that our gut bacteria play a big role in the state of our health. Many of us know now that a healthy composition of gut bacteria can improve our digestion, prevent embarrassing symptoms related to poor digestion and even prevent infections such as colds and flu. But did you know that they can also affect aging and longevity?

Research shows that as we get older, both our gut bacteria counts and the number of species declines. This is not just an inconsequential symptom, as a decline in microbiome (the "ecosystem" of bacteria inside our digestive system) quality can raise the risk of digestive, immune and even neurological conditions. You may also not know that there are now many people over the age of 100 (known as "centenarians") who are healthy and vital enough to live independently. Studies on them have shown too that independent centenarians have a higher diversity in their gut microbiomes than centenarians living in aged care homes or other assisted living facilities. Of course, worse off still are those who haven't lived to this age.

Kimchi. Source: Alan Chan (CC 2.0)

So how can we increase the diversity of our microbiome? One way is to become more in touch with nature, as urban environments cut off our exposure to many beneficial, commensal microbes. This may be a reason why "green" and "blue" spaces are linked with improved mental and cardiovascular health, as well as reduced mortality rates. When you are spending time inside, indoor plants can make your environment much healthier.

Traditional fermented foods are another way to improve our intestinal microbiome. In a small trial, prediabetic patients were instructed to consume either 1-day or 10-day fermented kimchi, which is a traditional Korean food. Both types of kimchi significantly reduced the average body weight, waist circumference and BMI. However, the 10-day fermented kimchi also decreased insulin resistance, and of course, increased insulin sensitivity. Only 9.5% of people eating 1-day old kimchi saw improved glucose tolerance, compared to 33.3% in the 10-day fermented group. Blood pressure also dropped significantly in the 10-day group, which has its own benefits. More general dietary advice is to eat a wide variety of foods; as different bacteria have different food sources, this can boost the diversity of your microbiome. However, it is important to avoid the foods you are intolerant or allergic to, and to get tested if you suspect any sensitivity. Gut inflammation can disrupt the microbiome and its communication with the immune system. Overall, you don't have to rely on "luck" or "fate" to live a long, healthy life. The secrets to longevity are hidden in plain sight.

Could Resveratrol Help Treat Alzheimer's Disease?

Alzheimer's Disease and other dementias are perhaps the worst kind of age-related disease there is. They affect everything about a person, not just the physical body, so anything that may help to slow or reverse these problems is definitely worth consideration. One of these interventions could be resveratrol, a much-studied natural substance with many potential antiaging effects.

For this study, 119 patients with mild-moderate Alzheimer's Disease were analysed. Of these, 19 took 1 gram of resveratrol twice daily, and 19 took a placebo, both for 52 weeks (one year). Resveratrol's antiaging effects are largely due to its ability to activate the SIRT1 gene. After 52 weeks, the treatment group showed signs that their levels of neuro-inflammation had fallen, and their immune systems were working more effectively. Resveratrol also slowed the decline in mini-mental status exam (MMSE) scores, as well as activities of daily living (ADL) scores. The decline in MMSE scores was not seen as statistically significant, meaning that it may not have truly deteriorated. The decline in ADL scores was half that of the placebo group. Additionally, the "normal" progression of Alzheimer's involves dysfunction and senescence of immune cells in the central nervous system. This impairs their ability to take out the cellular and interstitial "garbage", which has serious implications for neurological health.

Red grapes are the top food source of resveratrol,
though therapeutic doses call for supplementation.

Resveratrol is known as a pharmacological mimic of calorie restriction, which is the act of consuming two-thirds of the normal energy requirements. Research has shown that this can prevent or postpone many of the complications of aging, which is why many people have found health benefits from various fasting techniques, e.g. the 5:2 diet or confining food intake to 8-12 hours each day. On the other hand, diabetes and obesity increase the risk of problems such as Alzheimer's Disease. Activation of sirtuin genes, especially SIRT1, appears to be one mechanism behind the benefits of calorie restriction.

Actually, calorie restriction itself has been found to impact neurodegenerative diseases and other health problems. This is partly because many of these involve chronic inflammation, and research has shown that alternate-day fasting can reduce levels of inflammatory markers. This has been linked with reductions in the symptoms of asthma and rheumatoid arthritis, and even improved functional outcomes in a mouse model of stroke. Fasting may even have beneficial effects on genetic disorders. An animal study on mice with Charcot-Marie-Tooth Type 1A found that intermittent fasting could also improve motor performance and reduce the demyelination that is responsible for functional decline. Without myelin, our nerve cells cannot transmit signals as effectively. The mechanism behind this was improved autophagy, which clears out garbage in the cells, and in this case it included inappropriate aggregates of myelin protein. Both Parkinson's and Alzheimer's diseases also involve inappropriate protein aggregation, in PD alpha-synuclein is involved, and in AD we see amyloid-beta and tau proteins causing trouble. The only problem with these fasting techniques is that, although they are not constant, we have been raised to think that non-pregnant adults must be constantly eating throughout the day, and that any food restriction is a "punishment". But with all of the research on intermittent fasting techniques, which would you prefer (as long as you are medically able to fast, and need to), a relatively small amount of pleasure and poor health, or some discipline in exchange for a great life?